Comparison of the effect of Dexamethasone - Metoclopramide combination and ondansetron in the prevention of nausea and vomiting in cesarean section under spinal Anesthesia

Introduction: Nausea and vomiting is one of the complications of spinal anesthesia in cesarean section. The aim of this study was to compare the effects of dexamethasonemetocloprmide with ondansetrone on preventing nausea and vomiting during spinal Anesthesia for cesarean section. Methods: In this study 212 pregnant women (17-45 years old) candidate for elective cesarean section with an ASA I-II were subjected to a randomized double blind clinical trial. Before spinal anesthesia was applied the first group received 8 milligram dexamethasone and 10 milligram metoclopramide intravenously, the second group received 8 milligram ondansetrone intravenously. Results: There were no significant differences between the two groups regarding the demographic variables, and also heart rate, systolic and diastolic blood pressures at before neuroaxial block and at 1, 3, 5 and 10 minutes after block. )P>0.05). The Apgar score between the two groups was significantly different at the first (P=0.028), fifth (P=0.001) and twentieth minute (P=0.019). The overall incidence of nausea was 11.3% with no significant difference between the groups (P=0.665). No patient in the dexamethasonemetocloprimde group experienced any vomiting and in the ondansetrone group only 5 patients (4.7%) had vomiting (P>0.05). Conclusion: The combination of dexamethasone and metocloprimde is effective in preventing nausea and vomiting during cesarean section in women who have no other pregnancy related complications.